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A protocol for assessing bias and robustness of social network metrics using GPS based radio-telemetry data

**Background** Social network analysis of animal societies allows scientists to test hypotheses about social evolution, behaviour, and dynamic processes. However, the accuracy of estimated metrics depends on data characteristics like sample …

How group structure impacts the numbers at risk for coronary artery disease: polygenic risk scores and nongenetic risk factors in the UK Biobank cohort

The UK Biobank (UKB) is a large cohort study that recruited over 500,000 British participants aged 40–69 in 2006–2010 at 22 assessment centers from across the United Kingdom. Self-reported health outcomes and hospital admission data are 2 types of …

A scoping review on bovine tuberculosis highlights the need for novel data streams and analytical approaches to curb zoonotic diseases

Zoonotic diseases represent a significant societal challenge in terms of their health and economic impacts. One Health approaches to managing zoonotic diseases are becoming more prevalent, but require novel thinking, tools and cross-disciplinary …

Genomic insights into the population history and adaptive traits of Latin American Criollo cattle

Criollo cattle, the descendants of animals brought by Iberian colonists to the Americas, have been the subject of natural and human-mediated selection in novel tropical agroecological zones for centuries. Consequently, these breeds have evolved …

Verifying origin claims on dairy products using stable isotope ratio analysis and random forest classification

Scientifically underpinning geographic origin claims will improve consumer trust in food labels. Stable isotope ratio analysis (SIRA) is an analytical technique that supports origin verification of food products based on naturally occurring …

A simulation study for multifactorial genetic disorders to quantify the impact of polygenic risk scores on critical illness insurance

With advances in genetic research, the understanding of the genetic structure of disease and the ability to predict disease risk have been enhanced. Polygenic risk scores (PRS) have been developed to assess a person’s risk of developing any heritable …

Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations (Bos taurus/indicus)

The phenotypic diversity of African cattle reflects adaptation to a wide range of agroecological conditions, human-mediated selection preferences, and complex patterns of admixture between the humpless Bos taurus (taurine) and humped Bos indicus …

Static and dynamic methods in social network analysis reveal the association patterns of desert-dwelling giraffe

Patterns of association in animal societies vary through space and time. Understanding such variation is key to predicting inter- and intra-population variation across factors as diverse as gene flow, disease transmission, and resilience to climate …

Computational modelling of Chromosomally Clustering Protein Domains In Bacteria

Background: In bacteria, genes with related functions - such as those involved in the metabolism of the same compound or in infection processes - are often physically close on the genome and form groups called clusters. The enrichment of such …

Fine-scale Inference of Ancestry Segments without Prior Knowledge of Admixing Groups

We present an algorithm for inferring ancestry segments and characterizing admixture events, which involve an arbitrary number of genetically differentiated groups coming together. This allows inference of the demographic history of the species, …